Population-weighted exposure to green spaces ties to lower COVID-19 mortality rates: A nationwide dose-response study in the USAResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, 진단, [키워드] adjusted adopted association buffer caused chronic disease confidence interval Contact with nature COVID-19 mortality COVID-19 pandemic Critical decrease distribution ecological Effect effect size environmental factors forest greater Health increase in investigated knowledge Landscape planning and design linear mechanism mitigate mixed-effects model Mortality mortality rate mortality rates Nearby nature Optimal dose of nature promote PROTECT Regulation Research risk of COVID-19 SARS-CoV-2 Sociodemographic USA with COVID-19 [DOI] 10.1016/j.scitotenv.2022.158333 [Article Type] Research article
A hybrid random forest deep learning classifier empowered edge cloud architecture for COVID-19 and pneumonia detectionResearch article Published on 2022-12-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy Affect Algorithm Classifier cloud computing complex computation conducted COVID-19 COVID19 CT scan dataset datasets deep deep learning detect diagnose effective Efficiency evaluate False positives forest global pandemic Healthcare industry heat Heat Transfer Search algorithm identify immunization inefficient Interaction less lung CT scan methodology offer outcomes overcome Patient Pneumonia predict PROTECT random Random forest resource Support the patient virus Web services X-ray [DOI] 10.1016/j.eswa.2022.118227 [Article Type] Research article
COVID-19 vaccine associated transverse myelitis-Evusheld as an option when vaccination is not recommended due to severe adverse eventsCOVID-19 백신 관련 횡단 척수염-심각한 부작용으로 인해 백신 접종이 권장되지 않는 경우 옵션으로 EvusheldArticle Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administer administration adverse event Adverse reaction antibody Autoimmune COVID-19 COVID-19 vaccine determine individual Inflammation mechanism MHRA Moderna mRNA vaccine monoclonal antibody Patient precluded prophylactic therapy PROTECT receiving resulting Safe SARS-COV-2 infection severe adverse event spike-protein therapy U.S. FDA vaccination [DOI] 10.1080/21645515.2022.2068338 PMC 바로가기 [Article Type] Article
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2Article Published on 2022-11-082022-11-15 Journal: EMBO Molecular Medicine [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 Administered administration ameliorated Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody betacoronaviruses bind catalytic activity catalytically active Clinical use COVID-19 decoy demonstrated effective entry receptor High dose Host increased survival Infection Inflammation inoculated intravenous intravenously K18-hACE2 mice Loss Lung injury mechanism neutralization potency neutralize omicron Omicron variant persist PROTECT receptor receptor. reduced sACE2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown substrate target the SARS-CoV-2 therapeutic efficacy therapeutic potential Treatment virus [DOI] 10.15252/emmm.202216109 PMC 바로가기
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamstersArticle Published on 2022-11-042022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta block Community COVID-19 vaccine current Delta delta variant detectable Efficacy eliminating expressed Fever Gamma hamster immunization Lineage Lung pathology maintain Neutralizing antibody response omicron P.1 pandemic predominant Prevent PROTECT SARS-CoV-2 strains SARS-CoV-2 variant sequence Spread titre Transmission Vaccine variants variants of concern vectored vaccine virus VoC VOCs [DOI] 10.1038/s41467-022-34439-7 PMC 바로가기
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2PArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Beta challenge coronavirus COVID-19 COVID-19 vaccine Delta dose Effectiveness hamster hamster challenge study highest live SARS-CoV-2 Live virus lung MVC-COV1901 neutralization Neutralizing antibody titer Omicron variant pathology prefusion PROTECT pseudovirus recombinant regimen S-2P SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 vaccine spike Spike protein subunit Subunit vaccine suggested vaccination Vaccines variant Variant of concern. variants variants of concern virus Wuhan [DOI] 10.1093/infdis/jiac153 PMC 바로가기
Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal StudyArticle Published on 2022-11-012022-11-16 Journal: Annals of laboratory medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome analyzed anti-S antibody BNT162b2 BNT162b2 mRNA ChAdOx1 collected Concentration coronavirus Coronavirus disease-19 COVID-19 delta variant demonstrated dose doses Effectiveness Efficacy eight healthcare worker help immunogenicity longitudinal NAbs Neutralizing neutralizing antibody occurred omicron outbreak pandemic predicted produced Prospective PROTECT reached regimen risk second dose study period the vaccine Three-dose vaccination. university hospital vaccination vaccination rate variant variants of concern Wuhan-Hu-1 [DOI] 10.3343/alm.2022.42.6.688 PMC 바로가기
Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19Article Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants [DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activityResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] acting activities addition Antimicrobial/Antioxidant bioactivity antioxidant Antiviral approach Bioavailability bioinformatics Compound compounds Delta derivative docking result docking study enzyme evaluated exhibited Free radicals identification Identification of the pharmacophore sites in vitro in-silico information Interaction microorganisms mutants NMR omicron Osiris pathogenic microorganism Petra Petra/Osiris/Molinspiration (POM) analyses pharmacophores PROTECT provided pyrazole Pyrazole Linked Sulfonamide Conjugates shown Structure synergistic target protein tested Toxicity X-ray diffraction [DOI] 10.1016/j.molstruc.2022.133605 [Article Type] Research article